|
Rheumatoid Arthritis
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
|
30423114 |
2019 |
|
Rheumatoid Arthritis
|
|
0.830 |
GeneticVariation
|
GWASDB |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
Rheumatoid Arthritis
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
Psoriasis
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
|
Primary biliary cirrhosis
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.
|
22961000 |
2012 |
|
Lupus Erythematosus, Systemic
|
|
0.730 |
GeneticVariation
|
GWASCAT |
Transancestral mapping and genetic load in systemic lupus erythematosus.
|
28714469 |
2017 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
|
25751624 |
2015 |
|
Sarcoidosis
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Identification of Immune-Relevant Factors Conferring Sarcoidosis Genetic Risk.
|
26051272 |
2015 |
|
Psoriasis vulgaris
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
|
26626624 |
2015 |
|
Rheumatoid Arthritis
|
|
0.830 |
GeneticVariation
|
GWASCAT |
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.
|
24532676 |
2015 |
|
Multiple Sclerosis
|
|
0.730 |
GeneticVariation
|
GWASCAT |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
|
24076602 |
2013 |
|
Platelet Count measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Rheumatoid Arthritis
|
|
0.830 |
GeneticVariation
|
BEFREE |
Finally, in a phenome-wide association study (PheWAS) assessing >500 phenotypes using electronic medical records (EMR) in >29,000 subjects, we found no convincing evidence for association of P1104A and A928V with complex phenotypes other than autoimmune diseases such as RA, SLE and IBD.
|
25849893 |
2015 |
|
Rheumatoid Arthritis
|
|
0.830 |
GeneticVariation
|
BEFREE |
Computational Molecular Phenotypic Analysis of PTPN22 (W620R), IL6R (D358A), and TYK2 (P1104A) Gene Mutations of Rheumatoid Arthritis.
|
30899276 |
2019 |
|
Rheumatoid Arthritis
|
|
0.830 |
GeneticVariation
|
GWASDB |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Rheumatoid Arthritis
|
|
0.830 |
GeneticVariation
|
GWASCAT |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Rheumatoid Arthritis
|
|
0.830 |
GeneticVariation
|
BEFREE |
Genetic overlap between PsA and RA was detected for the rs34536443 SNP of the TYK2 gene within a Greek population.
|
27440135 |
2017 |
|
Psoriasis
|
|
0.810 |
GeneticVariation
|
GWASDB |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
|
Psoriasis
|
|
0.810 |
GeneticVariation
|
BEFREE |
No significant changes in p-STAT4 for the psoriasis-associated variant rs34536443 was found.
|
29728633 |
2018 |
|
Oligoarticular Juvenile Idiopathic Arthritis
|
|
0.800 |
GeneticVariation
|
GWASDB |
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis.
|
23603761 |
2013 |
|
Primary biliary cirrhosis
|
|
0.800 |
GeneticVariation
|
GWASDB |
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.
|
22961000 |
2012 |
|
Oligoarticular Juvenile Idiopathic Arthritis
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis.
|
23603761 |
2013 |
|
Autoimmune Diseases
|
|
0.750 |
GeneticVariation
|
BEFREE |
Cytokine responses for two associated variants (R231W, rs201917359; and R703W, rs55882956) in <i>TYK2</i> as well as a previously reported risk variant (P1004A, rs34536443) for multiple autoimmune diseases were evaluated by reporter assays.
|
31118190 |
2019 |
|
Autoimmune Diseases
|
|
0.750 |
GeneticVariation
|
BEFREE |
Genome wide association studies have linked a SNP (rs34536443) within <i>TYK2</i> encoding a Proline to Alanine substitution at amino acid 1104, to protection from multiple autoimmune diseases including systemic lupus erythematosus (SLE) and multiple sclerosis (MS).
|
30740104 |
2019 |
|
Autoimmune Diseases
|
|
0.750 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |